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Escin, also known as Aescin, is a natural saponin mixture extracted from the horse chestnut tree (Aesculus hippocastanum), known for its significant anti-inflammatory, vasoconstrictive, and vasoprotective effects. As the primary active component of the horse chestnut, Escin plays a crucial role in promoting blood circulation and reducing edema. The mixture's main active compound, β-Escin, along with other components such as α-Escin, protoescigenin, barringtogenol, cryptoescin, and benzopyrones, contribute to its wide range of pharmacological activities. Studies have shown that Escin, especially pure β-Escin, is a safe and effective short-term treatment for chronic venous insufficiency, although more high-quality randomized controlled trials are needed to confirm its overall effectiveness. Moreover, horse chestnut extract has been proven to have similar efficacy and tolerability to the use of compression stockings in clinical applications.

七葉樹素, Escin, 馬栗樹提取物, 抗炎, 保護血管, 慢性靜脈功能不全, β-七葉樹素, 化妝品 添加物, 化妝品 成分, 保養品 成分, 保養品 添加物, Aescin, horse chestnut extract

By Fvasconcellos - Own work, Public Domain, https://commons.wikimedia.org/w/index.php?curid=4428061

Effects in Cosmetics

Escin offers multiple benefits and applications, including:

Its anti-inflammatory properties can soothe sensitive skin and reduce redness and swelling.
Promotes blood circulation, helping to reduce puffiness around the eyes and even out skin tone.
Strengthens blood vessel walls, potentially benefiting the reduction of varicose and spider veins' appearance.


Primarily extracted from the seeds of the horse chestnut tree.
The extraction process involves grinding the seeds into powder and then extracting the active ingredients with solvents like water or alcohol.
After purification, the extract is ensured to contain a high concentration of Escin, especially β-Escin, to exert its pharmacological effects.

Globally Harmonized System of Classification and Labelling of Chemicals 


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