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苯甲酸

Benzoic Acid

Benzoic Acid, with the chemical formula C6H5COOH, is a white (or colorless) solid organic compound. Its structure consists of a benzene ring (C6H6) with a carboxyl (−C(=O)OH) substituent. Benzoic Acid is the simplest aromatic carboxylic acid. Its name is derived from gum benzoin, which was for a long time its only source.

Benzoic Acid occurs naturally in many plants and serves as an intermediate in the biosynthesis of many secondary metabolites. Salts of benzoic acid are used as food preservatives. Benzoic acid is an important precursor for the industrial synthesis of many other organic substances. The salts and esters of benzoic acid are known as benzoates.

苯甲酸, Benzoic Acid, 化妝品添加物, 化妝品成分, 保養品成分, 保養品添加物, 食品防腐劑, pH調節劑, 自然植物提取, 工業合成, 苯甲酸鹽

By NEUROtiker - Own work, Public Domain, https://commons.wikimedia.org/w/index.php?curid=3228267

Effects in Cosmetics

Benzoic Acid has a variety of effects and applications, some of which are listed below:

As a preservative in foods and cosmetics, inhibiting the growth of mold, yeast, and some bacteria.
Used as a pH adjuster in cosmetics, helping to maintain the stability and safety of the product.

Source or Extraction Method

Benzoic Acid is widely found in nature in many plants, such as cranberries, apples, etc.
Industrially, benzoic acid is typically produced by the partial oxidation of toluene, catalyzed by cobalt or manganese naphthenates.

GHS危險符號/歐盟危險性符號

1.代謝過程:

  • 苯甲酸在體內首先被丁酸-CoA連接酶代謝成中間產物苯甲酰-CoA。
  • 然後,甘氨酸N-酰基轉移酶將其進一步代謝成馬尿酸,最終以馬尿酸的形式排出體外。
  • 人體代謝甲苯時,同樣會產生並排出馬尿酸。

2.人類攝入建議:

  • 世界衛生組織的國際化學品安全計劃建議,人類的暫定可容忍攝入量為每天每公斤體重5毫克。

3.動物耐受性差異:

  • 貓對苯甲酸及其鹽的耐受性遠低於大鼠和小鼠。
  • 貓的致死劑量可低至每公斤體重300毫克。
  • 大鼠的口服LD50為3040毫克/公斤,小鼠則為1940-2263毫克/公斤。

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